𝐀𝐧𝐭𝐢𝐛𝐢𝐨𝐭𝐢𝐜𝐬 𝐚𝐧𝐝 𝐦𝐢𝐜𝐫𝐨𝐛𝐢𝐨𝐭𝐚: 𝐩𝐡𝐚𝐠𝐞𝐬, 𝐚𝐥𝐥𝐢𝐞𝐬 𝐨𝐟 𝐫𝐞𝐬𝐢𝐥𝐢𝐞𝐧𝐜𝐞.

🧬 Antibiotics disrupt the gut microbiome, but what happens to phages—the viruses that infect bacteria?
This study followed 22 healthy individuals 2 weeks before and up to 6 months after a 3-day course of third-generation cephalosporins.

𝐓𝐡𝐢𝐬 𝐰𝐚𝐬 𝐚 𝐡𝐮𝐠𝐞 𝐜𝐨𝐥𝐥𝐚𝐛𝐨𝐫𝐚𝐭𝐢𝐯𝐞 𝐰𝐨𝐫𝐤 𝐰𝐢𝐭𝐡 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫𝐬 𝐟𝐫𝐨𝐦 MetaGenoPolis -INRAE, Inra - Institut national de la recherche agronomique (France) and Inserm.

🔍𝘒𝘦𝘺 𝘧𝘪𝘯𝘥𝘪𝘯𝘨𝘴:
✔️Gut phages rarely carry antibiotic resistance genes.
✔️Most are temperate phages, including many phage-plasmids.
✔️Phage populations remain highly individual-specific, even after treatment.
However: just one day after antibiotics, phage diversity drops by 20% 📉, with blooms of a few predominantly virulent phages. This diversity was able to recover afterwards.
✔️Some of these phages may support bacterial recovery through “kill-the-winner” dynamics. They target the bacteria that became dominant following antibiotic treatment.

💡 𝘛𝘢𝘬𝘦-𝘩𝘰𝘮𝘦 𝘮𝘦𝘴𝘴𝘢𝘨𝘦:
𝐩𝐡𝐚𝐠𝐞𝐬 𝐚𝐫𝐞 𝐞𝐬𝐬𝐞𝐧𝐭𝐢𝐚𝐥 𝐩𝐥𝐚𝐲𝐞𝐫𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐦𝐢𝐜𝐫𝐨𝐛𝐢𝐨𝐦𝐞’𝐬 𝐫𝐞𝐬𝐩𝐨𝐧𝐬𝐞 𝐭𝐨 𝐚𝐧𝐭𝐢𝐛𝐢𝐨𝐭𝐢𝐜𝐬, 𝐡𝐞𝐥𝐩𝐢𝐧𝐠 𝐫𝐞𝐬𝐭𝐨𝐫𝐞 𝐛𝐚𝐥𝐚𝐧𝐜𝐞 𝐚𝐧𝐝 𝐦𝐢𝐜𝐫𝐨𝐛𝐢𝐚𝐥 𝐝𝐢𝐯𝐞𝐫𝐬𝐢𝐭𝐲.

https://pubmed.ncbi.nlm.nih.gov/40694475/