Prediction of the intestinal resistome by a threedimensional structure-based method

november 30, 2018

The gut microbiome harbours a vast diversity of antibiotic resistance determinants (ARDs). At MetaGenoPolis, scientists developped a new innovant method based on 3D in order to predict & study the diversity of intestinal AR genes in the gut microbiome. Indeed, they developed and validated an annotation method on the basis of a three-dimensional structure (PCM), leading to the prediction of 6,095 ARDs from the human gut microbiome. Scientists found little evidence supporting their transfer between species: ARDs for the most part unlikely to be transferred to pathogenic bacteria. Finally, according to the composition of their resistome, authors were able to cluster subjects from the MetaHIT cohort into six resistotypes.

https://www.nature.com/articles/s41564-018-0292-6

https://www.pasteur.fr/fr/espace-presse/documents-presse/plus-6000-genes-resistance-aux-antibiotiques-decouverts-microbiote-intestinal

ABOUT THE AUTHOR

MGP

MetaGenoPolis

INRAE center - Metagenomics expertise for human and animal microbiome research

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